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Paper Details

HEART RATE VARIABILITY IN PATIENTS WITH LIVER CIRRHOSIS A MARKER FOR AUTONOMIC DISFUNCTION

Robert D. NEGRU, Doina-Clementina COJOCARU, Anca TRIFAN, Corina DIMA-COZMA

Journal Title:International Journal of Medical Dentistry
Abstract


The study aimed at evaluating the potential correlations between heart rate variability (HRV) parameters and liver cirrhosis severity and etiology, and at estimating the type of autonomic disfunction induced, over a 24 hour Holter monitoring. Methods. Included in the study were 48 patients with liver cirrhosis and 30 control subjects, submitted to a 24-hour ECG recording, whose time and frequency domain HRV parameters were analyzed. Results. The imbalance between the two autonomic components was reflected in significantly lower values recorded for the time-domain parameters (mean RR, SDNN, SDNN index and SDANN index), LF (P = 0.02) and LF/HF ratio (P < 0.001) in cirrhosis versus controls, except for HF, r-MSSD and pNN50, which suggests a markedly decreased sympathetic activity, with the vagal component less impaired. Alcoholic etiology recorded the most important impairment of HRV parameters. Conclusions. The 24-hour ECG monitoring of HRV parameters could help in establishing the noninvasive prognostic markers in patients with liver cirrhosis.

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