• We are available for your help 24/7
  • Email: info@isindexing.com, submission@isindexing.com


Paper Details

CHARACTERIZATION OF GREVILLEA ROBUSTA GUM TO ESTABLISH IT AS A PHARMACEUTICAL EXCIPIENT

*Darekar AB, Kahane JU, Saudagar RB, Gondkar SB, Chavan MJ, Ashawat M

Journal Title:World Journal of Pharmaceutical Research
Abstract


The gums are common constituents of plants, being used in pharmaceutical and in other various industries due to their abundance in nature, safety and low cost. The present study was undertaken to isolate gum from the plant of Grevillea robusta, to explore its use as a pharmaceutical excipient. The isolated gum was evaluated for various physico-chemical characterizations. The parameters applied from the present study included solubility, hygroscopicity study, moisture content, ash values, swelling index, hydration capacity, angle of repose, bulk and tapped density, Hausners ratio, compressibility index, pH value, rheological study, microbial co unt and acute toxicity study. The results obtained in the acute toxicity study indicated that Grevillea robusta gum did not produced any visible toxicities or mortality with oral doses up to 2000 mg/kg within 24h of single treatment. Scanning electron micr oscopy (SEM), X-ray powder diffraction (XPRD), Differential scanning calorimetry (DSC), and Fourier transmittance infra-red (FTIR), were used to characterize the gum sample which could be used further for the formulation development.

Download