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Paper Details

COMPARATIVE ACCOUNT ON MEDICINAL IMPORTANCE OF MOMORDICA CHARANTIA AND ITS ENDOPHYTES

Sarika R. Deshmukh*, Yogita K. Dhas and B.A. Patil

Journal Title:World Journal of Pharmaceutical Research
Abstract


This research was aimed to study comparative account of Momordica charantia plant extract and its endophytes. Crude fruit, leaf and endophytic extracts of bitter gourd cooperated with antibiotics; streptomycin and tetracycline against four bacteria. The antimicrobial activity of bitter gourds extract with two antibiotics was tested against Escherichia coli, Salmonella typhi, Bacillus subtilis and Staphylococcus aureus. All isolated endophytes showed the maximum zones of inhibition against all four bacterial strains. The values of minimal inhibitory concentration (MIC) was determined and the results had been obtained as all extracts showed that there was gradual decrease of optical density with increase in concentration of extract. After MIC determination of the crude and endophyte extracts, the extracts that showed maximum inhibition was further evaluated for MBC values. All endophytic extracts showed minimum bacterial colonies against all four bacteria. Then cytotoxicity was determined on cancer cell line (HeLa cell line). Thus, the crude fruit and all endophyte extracts were shown the highest antiproliferative activity which was ranged from 70 to 96%.

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