Computational Genome analysis of Hypotetical Protein in Mycobacterium laprae TN For Therapeutic Drug Target Identification
Journal Title:INTERNATIONAL RESEARCH JOURNAL OF SCIENCE AND ENGINEERING
Mycobacterium laprae Bacteria were selected .In this bacteria hypothetical protein were selected . The present study is aimed at predicting the 3-dimensional structure of AcylCoA Synthetase protein in M.leprae, which play a pivotal role in fatty acid metabolism and to find the active site of the protein, which is used as a strategy in drug design. The study was done by using different Bioinformatics tools. In silico differential genomics helps to identify genes that encode for unique metabolism with relation to human. The genomic database provides a vast amount of useful information for the drug target identification. The study revealed that Acyl-CoA Synthetase protein in M.leprae play an important role in fatty acid metabolism whose 3dimensional structure has not yet been solved. By confirming the structure of the modeled protein experimentally and knowing its active site helps in designing of effective Anti-Myobacterial drugs.