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Paper Details

PERSEVERANCE OF MARINE ACTINOMYCETES ISOLATED FROM GULF MANNAR EAST COSTAL REGION AND ITS ANTIMICROBIAL ACTIVITY

M. Mohamed Mahroop Raja* and S. Ahmed John

Journal Title:World Journal of Pharmaceutical Research
Abstract


The objective of present work is to explore marine Actinomycetes and its antibacterial effect against Multidrug resistant pathogens. Sample of marine sediments collected from Gulf Mannar East costal region, Kayalpatnam located at Tuticorin district of Tamil nadu, India. A Total of 19 Actinomycetes strains isolated from marine sediments. Actinomycetes are characterized by both macroscopic and microcopy studies. Analysis of morphological, physiological and cultural characterization suggested that Actinomycetes isolates were belongs to the genus of Streptomyces sp, Micromonospora sp, Micropolyspora sp, Strptoverticilium sp and Intrasporangium sp. Among these isolates Stereptomyces sp were exhibited dominant level followed by Micromonospora sp. The frequency of isolated marine Actinomycetes were found to be 53% Sterptomycetes sp, 32% Micromonospora sp followed by 5% of Micropolyspora sp, Strptoverticilium sp and Intrasporangium sp. Among the 19 tested Actinomycetes, two Sterptomycetes sp designated as KPMS 5 and KPMS 14 showed potent antimicrobial activity against Multidrug resistant E.coli, Klebsiella pneumoniae, Proteus mirabilis and Staphylococus aureus. The result of this investigation revealed that the marine sediments can be useful for the isolation of novel species of Actinomycetes producing potent source of novel bioactive compounds. Further investigations are needed in order to determine the active metabolites of these isolates.

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