DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR CHLORTHALIDONE IN BULK AND PHARMACEUTICAL DOSAGE FORMS
*Sapana U. Ingle, Pallavi A. Patil, Vaishali C. Kulkarni, Sheetal V. Patil, Poonam A. Salunke, Rupali S. Wagh.
Journal Title:World Journal of Pharmaceutical Research
A new, simple, accurate, rapid and precise spectrophotometric method
has been developed for validation of chlorthalidone (CTD) in bulk
drug. An attempt was made to preclude the use of corrosive inorganic solvents by the use of 0.2 M NaOH. The developed method was the
measurement of absorptivity at 274.5nm (absorption maximum of CTD). The results of analysis have been validated as per ICH
guidelines. The Concentrations of this drug were evaluated in laboratory mixture and marketed formulation. Accuracy was
determined by recovery studies from marketed formulation and Ranges From 97.87-107.39%. Precision of method was find out as repeatability shows the values within acceptable limit.