ANTIFUNGAL ACTIVITY OF BURSERA PENCILLATA LEAF EXTRACT ON DERMATOPHYTES
Ashok. T* Madhuri. N,Sravanthi.P
, Shilpa Vemula
Journal Title:World Journal of Pharmaceutical Research
To evaluate the in v i t ro ant ifungal act ivit y of Bursera pencillata
leaf extract s and fractions on t he clinical isolat es of der mat ophyt ic fungi like Tric hophyt on ment agr ophytes, Tri chophyton rubrum,
Mi crosporum cani s, Mi crosporum gypseum and Epidermophyton floccosum.
The minimum inhibitory concentrati on (MIC) and minimum fungici dal
concentrati on (MFC) of various extracts and fract ions of the leaves of
Bursera pencillata were measured using method of Nat iona l Commit tee for Clinical Laborator y Standards ( NCCLS). Bursera
pencillata leaf extracts and fractions were found to have fungicida l
activity against various clinical isolates of dermatophyti c fungi . The MIC and MFC was found to be high in water and ethyl alcohol extracts and
methanol fractions (200 g /mL) against dermatophytic fungi studi ed.
Bursera pencillata l eaf extracts significantly inhibits the growth of all dermatophyti c fungi
studi ed. If this activity is confirmed by in vivo studi es and if the compound is isolated and
i denti fied, i t could be a remedy for dermatophytosis