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Paper Details

EFFECT OF PURE MANGIFERIN VIS-A-VIS CRUDE ETHANOLIC EXTRACT FROM MANGIFERA INDICA BARK ON HAEMATOLOGICAL PARAMETERS IN MALE ALBINO RATS

Arnab Das, Chaitali Bose, Subhasish Ghosal, Indrani Chakraborty, Nirmal Pradhan*

Journal Title:World Journal of Pharmaceutical Research
Abstract


Different parts of mango tree have great medicinal value in different clinical fields. But the bark extract is very important in the field of pharmaceutical research and clinical applications. The present study was conducted to evaluate the effect of crude ethanolic extract (mother) of Mangifera indica bark in comparison to pure mangiferin on haematological indices in adult male albino rats. In this study, eighteen animals were divided at random into three groups i.e. vehicle control, M.indica bark extract and pure mangiferin, which received intraperitoneally 0.1ml 70% methanol, 0.1ml bark extract and 1mg pure mangiferin in 0.1ml 70% methanol/100gm b.wt./day accordingly for consecutive 14 days. Result s showed no change in body growth rate, weights of heart and lung, where weights of adrenal and spleen were significantly increased in extract treated group than control. But the weights of kidney and spleen were reduced in pure mangiferin group in respect to extract treatment. Significant reduction of liver weight was observed in pure mangiferin group than control. The SGOT, SGPT and serum ALP showed no significant change. Haematological indices like Hb, TC of RBC and PCV were significantly increased in pure mangiferin group when compared to control. Notably, TC of RBC was also significantly high in pure mangiferin group when compared to extract treatment. But MCV and MCH showed significant reduction in pure mangiferin group than control and extract treat ment. The MCHC showed no change. TC of WBC was significantly higher in treated groups than control. From the results, it may be concluded that mangiferin of M.indica bark extract may be an active haemopoietic principle, which can be therapeutically used for haemopoiesis.

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