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Paper Details

EFFECT OF METHANOLIC EXTRACT OF ANANAS COMOSUS LEAVES ON GLUCOSE TOLERANCE AND ACETIC ACID-INDUCED PAIN IN SWISS ALBINO MICE

M.M. Faisal, Fairuj Maliha Mhazabin Hossa, Shahnaz Rahman , A.B.M. Anwarul Bashar, Shahadat Hossan, Mohammed Rahmatullah*

Journal Title:World Journal of Pharmaceutical Research
Abstract


In oral glucose tolerance test (OGTT), methanol extract of Ananas comosus leaves, when administered orally to glucose-loaded Swiss albino mice at doses of 50, 100, 200 and 400 mg/kg body weight led to dose-dependent reductions in blood glucose levels. At these doses, the percent reductions in blood glucose levels were, respectively, 6.5, 20.2, 30.5, and 46.9% compared to control animals. A standard ant hyperglycemic drug, glibenclamide, when administered at a dose of 10 mg/kg body weight reduced blood glucose levels by 47.3%. The extract at the afore-mentioned four doses, also dose-dependently reduced acetic acid-induced abdominal constrictions in mice by 29.6, 37.0, 44.4, and 48.1%, respectively. A standard analgesic drug, aspirin, when administered at doses of 200 and 400 mg/kg reduced the number of abdominal constrictions, respectively, by 44.4 and 55.6%. Preliminary phytochemical screening showed presence of alkaloids, flavonoids, saponins and tannins in the extract, which components can be responsible for the observed blood glucose lowering and analgesic effects.

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