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Paper Details

EFFECT OF SUBACUTE ORCHIDECTOMY ON HEAMATOLOGICAL PARAMETERS AND LIPID PROFILE IN WISTAR RATS

*Sulaiman I,Dissi, G.M, Mabrouk, M.A. Gotam K, Shamim A K , Khairi CM, Nordin S, Atif, A.B

Journal Title:World Journal of Pharmaceutical Research
Abstract


The effect of hypogonadism on some cardiovascular risk factors remains controversial and occasionally conflicting. This study was designed to determine the effect of orchidectomy induced hypogonadism on some hematological predictors of cardiovascular health status and body defense system. Fifty Wistar rats (25 male and 25 females) were used for this study. Male wistar rats were grouped into five groups (n=5), Group 1 consisted of the bilaterally orchidectomized rats, Group 2 were unilaterally castrated, Group 3 were sham operated, while group 4 and 5 were the experimental and passive controls respectively. The study lasted for six weeks. Conventional methods were applied for sample collection. Laboratory analysis of concentrations of testosterone, FSH, LH, lipid profile, full blood count, ESR, PCV and Hb concentration were conducted. Data was subjected to statistical analysis using one way analysis of variance (ANOVA) to compare means (P ? 0.05). Bilateral orchidectomy was found to significantly decrease testosterone concentration (65.62%), triglycerides concentration (17.52%), red blood cell count (53.24%), total white blood cell count (54.64%) and percentage lymphocytes (26%) in the differentials. Significant increase in concentrations of LH (82.81%), FSH (97.12%), MCV (70.76%), MCH (76.23), total cholesterol (12.45%), LDL (25.34%) and percentage neutrophils relative to the differentials (69.4%) were also observed in the group. No significant change in PCV, Hb, MCHC, thrombocyte count, ESR, HDL. In conclusion, bilateral orchidectomy lead to characteristic macrocytic normochromic aneamia, increased susceptibility to infection and dyslipideamia associated with hypercholesteroleamia and elevated LDL concentration which may increase atherosclerotic plaques formation. Though the procedure may be used in a number of procedures, the subacute complications that follows the procedure appears to be highly detrimental to healthy leaving.

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