A REVIEW ON TARDIVE DYSKINESIA AND ITS MANAGEMENT
Gamini N S Santhoshi Lakshmi*
, Dr.Singuru Kiran Kumar,
Kodamanchili Vidya Bharghavi,
Kesava Rao Kannuru, Pasam Ravi Sankar,Datla Divya Bharathi.
Journal Title:World Journal of Pharmaceutical Research
Tardive dyskinesia is a movement disorder and it is usually associated with the chronic use of first generation antipsychotics which includes
involuntary rapid movements of face and body like grimacing, tongue movements, lip smacking, lip puckering, pursing of the lips, excessive
eye blinking, rapid and involuntary movements of the limbs, torso, and
phalanges. With the availability of second generation antipsychotics,
the risk of tardive dyskinesia is decreased to some extent. The
pathophysiology of tardive dyskinesia was not completely understood but the possible mechanisms include post-synaptic dopamine receptor
hypersensitivity, striatal GABA neurons abnormality, and striatal
cholinergic inter-neurons degeneration. There is no evidence based
treatment which is effective in treating the tardive dyskinesia till date. Several drugs have
been tried to determine their efficacy in decreasing the symptoms of tardive dyskinesia.