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Paper Details

SOLID LIPID NANOPARTICLES: A PROMISING AND NOVEL DRUG DELIVERY SYSTEM - A REVIEW

Kinjal Patel*, Divakar Goli, Soma Pramanik

Journal Title:World Journal of Pharmaceutical Research
Abstract


Solid lipid nanoparticles is the rapidly emerging field of nanotechnology with numerous potential applications in drug delivery, clinical medicine, cosmetics and research, as well as in other varied sciences. Solid lipid nanoparticles, colloidal drug carrier for incorporating hydrophilic or lipophilic drugs, the ability to incorporate drugs into nano-carriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Due to their unique size-dependent properties, lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researcher. This article gives an outline about the potential advantages and disadvantages of solid lipid nanoparticles, the excipients and all the different methods involved in the production. The characteristic of SLN stability and secondary steps involved in their stabilization like freeze drying, sterilization etc. Analytical methods involved in SLN evaluations are discussed in detail. The route of administration and current applications are mentioned in the article.

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