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Paper Details

Synthesis and Characterization of 2H-Pyrrole-2-Ones of (5-Benzoyl-benzoimidazol-1-yl)-acetic acid hydrazide derivatives

Deepak Kumar*, Arun Singh** and Yogesh Kumar Walia***

Journal Title:Asian Journal of Advanced Basic Sciences
Abstract


ABSTRACT: The present study deals with the heterocyclization of Schiff bases of (5-Benzoyl-benzimidazol-1- yl)-acetic acid hydrazide [BBAH] into (2H)-Pyrrole-2-ones derivatives. One of the hydrazide i.e. 2-hydroxy benzoic acid hydrazide (salicylhydrazide) and their condensed product play a vital role in medicinal chemistry. More particularly and recently these types of compounds have been found in the treatment of T.B. and other chemotherapeutic diseases. Hence, it was thought of interest of merging of both pyrrole and benzimidazole hydrazide moieties may enhance the drug activity of compound up to some extent or might possess some biological activity. From this point of view the objective of present works to prepare new derivatives of benzimidazole hydrazide containing a pyrrole moiety. Hence The present study deals with the heterocyclization of Schiff bases of (5-Benzoyl-benzimidazol-1-yl)-acetic acid hydrazide [BBAH] into (2H)- Pyrrole-2-ones derivatives. Keywords: (5-Benzoyl-benzimidazol-1-yl)-acetic acid hydrazide, Pyrrole, spectral studies.

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