Potentiometric determination of Stability Constant of Levofloxacin and Mn (II) Ion Complex
Namita Bhardwaj* & Dr. M. K. Singh**
Journal Title:Asian Journal of Advanced Basic Sciences
ABSTRACT: Transition metal complexes are cationic, anionic or neutral species in which transition metal is
coordinated by ligands. Metals can play an important role in modifying the pharmacological properties of
known drugs after coordinating with it. Stability constants of complexes also have an important role in the
design of drugs for alleviation of metal poisoning. In the present study levofloxacin is used as a ligand for
complexation. It is a member of fluoroquinolones group of antibiotics which is very active against aerobic
Gram negative microorganism. The object of the present work is a physicochemical investigation of the
interaction of bivalent metal ion [Mn(II)] with levofloxacin antibiotics and is aimed at understanding the
mechanism of inhibitory or lethal effect of antibiotics against fixed types of microorganisms. The stability
constants data can also be used for determination of various thermodynamic parameters such free energy
(?G0), enthalpy (?H0), and entropy ?S0. From these parameters important information about mechanism of
interaction can be deduced.
Key Words: Ligand, Stability constant, Complexation, Complex, Thermodynamic parameters.