EFFECT OF HYDROALCHOLIC PERICARP EXTRACT OF MOMORDICA CHOCHINCHINENESIS ON HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC ACTIVITIES IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS.
Swathi Putta, *Eswar Kumar Kilari
Journal Title:World Journal of Pharmaceutical Research
Diabetes mellitus is a chronic metabolic disorder characterized by raise
in blood glucose levels known as hyperglycemia. The prev alence of diabetes were found to be 246 million by Wayne Katon J, 2008 and
estimated to be 325 million at 2025. In the present study, the
hydroalcoholic pericarp extract of Momordica chochinchinensis
(HAPMC) was evaluated for hypoglycemia and its antihyperglycemic
activity in streptozotocin-induced diabetic rats. The % inhibition of blood glucose levels in hypoglycemic activity of HAPMC 150 mg/kg and 300 mg/kg were found to be 28.18% (3h) & 23.9% (6h) and 32.75% (3hr) & 23.6%(6 hr) hypoglycaemic normal rats. The ant hyperglycemic activity of HAPMC with 150 mg/kg and 300 mg/kg in
STZ induced diabetic rats were found to be 32.94% and 36.47% at 6hr respectively. The biphasic reduction was observed in both in normal and diabetic rats mi ght
be due to biphasic absorption or biliary secretion of the active principle present in HAPMC. Further the samples from diabetic rats were estimated for lipid profile. The lipid profile
parameters were significantly brought back to near normal by the treatment if HAPMC for 12
weeks. At the end of 12 weeks study period the serum parameters like bilirubin, creatinine, total protein, albumin, uric acid and urea were found to be increased in diabetic rats and treatment with HAPMC there is a significant reduction in all the parameters. In conclusion,
the HAPMC found to have significant ntihyperglycemic, antihyperlipedemia activity and significant protection against the damage to kidney. Which might be due to antioxidant potential present in the HAPMC.