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Comparative Study of Analgesic Effect of Epidural Clonidine and Magnesium Sulfate as an Adjuvent to Bupivacaine in Orthopaedic Lower Limb Surgeries

Comparative Study of Analgesic Effect of Epidural Clonidine and Magnesium Sulfate as an Adjuvent to Bupivacaine in Orthopaedic Lower Limb Surgeries

Dr. Abhishek Choudhary, Dr. Saheer Ahmed Siddiqui, Dr. Rambabu Sharma, Dr. Nitin Johar, Dr. Meenaxi Sharma

Journal Title:GLOBAL JOURNAL FOR RESEARCH ANALYSIS
Abstract


BACKGROUND: This prospective double blind, randomized controlled trial study was undertaken to compare the onset and duration of analgesia with the epidural bupivacaine and its combination with either magnesium sulphate or clonidine, to establish the ideal combination of drug with least side effects. MATERIAL & METHODS: The study included 90 patients between age group 20-60 yrs. of ASA grade I & II, scheduled for orthopaedic lower limb surgery. Patient were randomly assigned to three groups of 30 patients each. Gr. I- 20 ml of 0.5% bupivacaine + 5ml of NS, Gr.II- 20ml of 0.5% bupivacaine + 50 mg magnesium sulphate + 4ml of NS and Gr. III- 2 ml of 0.5% bupivacaine + 50 mic.g clonidine + 4 ml of NS. The time of injection, onset of analgesia, level of sensory and motor block, hemodynamic changes and side effects were recorded. RESULTS: The time of onset of sensory analgesia is least with clonidine, the time of regression of sensory analgesia to L1 segment is maximum with clonidine, time for onset of motor block is least in clonidine group, the grade of motor block is maximum in clonidine group, hemodynamic effects and side effects were not significant. CONCLUSION: we conlcuded that we have quicker time of onset of sensory and motor blockade, greater duration of analgesia, with no significant increase in side effects with clonidine group than the magnesium sulphate group.

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