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Paper Details

Frequency of Insulin Resistance Among Hepatitis C Virus Patients With or Without Oesophageal Varices

Frequency of Insulin Resistance Among Hepatitis C Virus Patients With or Without Oesophageal Varices

Ashraf Metwally, Waseem M. Seleem, Nagwa Shawky

Journal Title:
Abstract


Background: Insulin resistance (IR) is directly associated with the severity of fibrosis in chronic hepatitis C virus (HCV) patients. HCV associated with IR may cause enhanced hepatic steatosis, resistance to anti-viral treatment, faster progression of hepatic fibrosis and cirrhosis with development of portal hypertension and oesophageal varices (OV). Aim of the work: The aim of this study is to estimate the frequency of IR among patients with HCV related cirrhosis with or without OV in an attempt to clarify the role of IR as a risk factor for developing OV in cirrhotic patients. Patients and methods: This study was performed on 120 patients with HCV related cirrhosis; 60 of them had endoscopic evidence of OV and 60 without OV. All patients included in this study were subjected to full history taking, thorough physical examination, laboratory investigations (complete blood count, liver function tests, anti- HCV antibodies, PCR for HCV, lipid profile, fasting and post prandial blood glucose, fasting insulin level with calculation of Homeostasis Model Assessment (HOMA) test to assess insulin sensitivity of the patients), abdominal ultrasonography and Esophagogastroduodenoscopy (EGD). Results: The frequency of IR was significantly higher among OV patients when compared to non-OV patients (61.7% vs 33.3% P

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