• We are available for your help 24/7
  • Email: info@isindexing.com, submission@isindexing.com


Paper Details

IN VITRO SCREEENING OF PHYTOCHEMICALS AND ANTICANCER ACTIVITY OF ARGEMONE MEXICANA LEAF EXTRACT

Selvaraj Varun, Sudha Sellappa*

Journal Title:World Journal of Pharmaceutical Research
Abstract


The present study investigates the qualitative and quantitative analysis of the major bioactive constituents of Argemone mexicana in aqueous, ethanol and methanol extract of root, stem and leaf. Phytochemical analysis of the root, leaves and stem extracts showed the presence of alkaloids, phenol, sugar, terpenoids, glycosides, flavonoids and tannins. The flavonoids and tannin contents were present in maximum level in the aqueous extract of A. mexicana leaf followed by stem and root extracts. MCF- 7 Breast cancer cells were treated with different concentrations of the aqueous extract of leaf at two different time intervals. Cell viability and apoptosis induction, were investigated. A.mexicana extract treated MCF-7 cells exhibited a marked increase in apoptosis as compared to untreated group and the data showed that the activity of caspase-3, -8 and -9 were significantly enhanced by A. mexicana treatment. Aqueous extract of the leaf showed dose-dependent cytotoxic and apoptotic effect in MCF-7 breast cancer cells. The phytochemical analysis of A.mexicana fetches pharmaceutical companies in the production of the new drugs against cancer.

Download