ANTIHYPERTENSIVE ACTIVITY OF Nardostachys jatamansi IN HYPERTNSIVE RATS FOLLOWING RENAL GOLD BLATT OCCLUSION METHOD.
V.Velpandian*, N.Anbu, S.Elangovan, M. Mohamed Musthafa
Journal Title:World Journal of Pharmaceutical Research
Siddha drugs are gaining popularity in recent years and there is a significant increase in scientific researches on traditional Siddha drugs because of theirs potent effects with no or less adverse effects.One of
the safest and potent anti-hypertensive drug from the reservoir in
Siddha system of medicine is Sadamanjil Chooranam (Nardostachys jatamansi). Hence an attempt was made to validate the antihypertensive potential of Sadamanjil Chooranam in hypertensive rats
following renal Goldblatt occlusion method. After induction, hypertensive rats were randomly divided into four groups each consists
of five rats. All the groups were categorized into normal control,
hypertension control, SMC 500 (500mg/kg) and SMC 1000 (1000mg/kg). The test drug Sadamanjil Chooranam was administered
(500mg/1000mg/kg) orally from the next day for 10 days. The systolic (SBP) and diastolic (DBP) blood pressure of the animals were recorded with tail cuff BP apparatus.
Administration of SMC at the dose levels of 500mg and 1000mg /kg b.w. for 10 days significantly decreases the Systolic BP and Diastolic BP as compared with hypertensive
animal group. Decrease in systolic and diastolic BP was more pronounced in high dose level (1000mg/kg) than low dose (500mg/kg) indicated the dose dependent activity of Sadamanjil Chooranam. The results concluded the anti-hypertensive potential of Sadamanjil Chooranam
in a scientific way.