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Paper Details

BARIATRIC SURGERY AND ITS EFFECT ON THE METABOLIC ASPECT IN DIET INDUCED OBES RAT MODEL

Surya Prakash Singh, Ramji Gupta*, Sokindra Kumar, Mukesh Kumar

Journal Title:World Journal of Pharmaceutical Research
Abstract


Bariatric surgery is the only treatment for obesity after failure of medication that may confers the definitive weight loss at long-term duration. Furthermore to weight loss there is a strong evidence to cure various co-morbid conditions originated with obesity like obstructive sleep apnea, hypertension, Type II diabetes mellitus, asthma, gastroesophageal reflux disease and osteoarthritis. While systematic study on the bariatric surgical mechanisms is still unknown. The main objective is to measure the effects of sleeve gastrectomy on the treatment of obesity and insulin resistance in high fat diet-induced obese (DIO) rats. Sleeve gastrectomy was performed in DIO rats. Food intake, body weight and fasting blood glucose were measured after SG. Blood plasmic parameter such as GLP-1, Gut harmone (Adipokines). Blood glucose, fasting ghrelin level and insulin during meal test from 1 to 3 and 5 month were measured periodically. The insulinogenic index and (HOMA) Homeostatic model assessment were measured between sleeve and sham operated rats. Sleeve gastrectomy (SG) play a potential role in producing weight loss and resolving in type 2 diabetes also show higher successive rates and lower mortality and represent reliable restrictive procedure to treat obesity and their associated co-morbidities.

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