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A Clinicopathologic Comparison of Cyclin D1-Positive and Cyclin D1-Negative Lymphomas with Mantle Cell Morphology

A Clinicopathologic Comparison of Cyclin D1-Positive and Cyclin D1-Negative Lymphomas with Mantle Cell Morphology

El-Esawy . B. H, H.Osman, El Askary A

Journal Title:
Abstract


Background:. MCL has an aggressive and incurable clinical course and frequent T(11;14)(q13;q32) translocation. The aim of this study was to investigate the value of cyclin D1 expression in B- cell non Hodgkin lymphoma with mantle cell morphology & study of clinico-pathological correlation. 171cases have been examined for lymphoma with MCL morphology from a viewpoint of cyclin D1 over expression, Using SPSS program. 138 cases (80.7%) showed positive nuclear staining for cyclin D1, while the remaining 33 (18.7%) were negative. The cyclin D1- positive group showed a higher age distribution (P .035), larger cell size (P.04), higher mitotic index (P .03) while the cyclin D 1 negative group showed significant CD 23 expression (P.003) Both cyclin D1- positive and -negative groups may represent different entities. Therefore, cyclin D1-positivity should be included as one of the standard criteria for MCL diagnosis and proper therapy

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