Effects of Dexmedetomidine on Hemodynamics in Patients Undergoing Laproscopic Surgeries under General Anaesthesia–A Comparative Study
Dr Yogesh Chauhan, Dr Heena Parikh
Background:Dexmedetomidine is a highly selective ?2 agonist with properties of sedation,analgesia and
anxiolysis, making it an ideal anaestheticadjuvant.We studied a randomized,double blind prospective study
to evaluate the efficacy of dexmedetomidine to provide perioperative hemodynamic stability in patients undergoing elective laparoscopic surgeries.We also studied the effects of dexmedetomidine on other anaestheticagents.Material and
Method:Sixty patients of either sex (18ndash;75 years)scheduled for elective laparoscopic surgeries were randomly allocated in one of the two groups containing 30 patients each.They received in a double blind manner,either a saline placebo or a
dexmedetomidineinfusion.Group D received dexmedetomidine intravenous infusion at a rate of 0.4µg/Kg/hr plus fentanyl.
Group C received 0.9% saline in the same rate plus fentanyl.Observation and Result:Afterpneumoperitoneum,mean value
of MAP(81.53plusmn;14.19 vs 98.63plusmn;19.75 Pvaluelt;0.05)and Heart rate(73.90plusmn;10.81 vs 91.53plusmn;15.63
Pvaluelt;0.05 )were significantly lower in Group D as compare to Group C.Similarly Group D blunted the tachycardic and
hypertensive respose to intubation as compare to Group C (P valuelt;0.05).Furthermore Group D also provided early emergence in comparison with Group C (P valuelt;0.05).Conclusion:Dexmedetomidine as a prendash;anaestheti medication and
intrandash;operative infusion is a simple,easyand economic general anaesthetic adjuvant that maintains stable hemodynamics and provides an excellent recovery profiles.