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Detection of Inducible Clindamycin Resistance in Staphlylococcous aureus isolates

Detection of Inducible Clindamycin Resistance in Staphlylococcous aureus isolates

Dr.B.Sreekanth, Dr. Gogi Suresh Dattaraya

Journal Title:
Abstract


Introduction :- The resistance to antimicrobial agents among staphylococci is an increasing problem. Clindamycin is considered to be one of the alternative agents in these infections. Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. Materials and methods :- A total of 238 S. aureus isolates were subjected to routine antibiotic susceptibility testing including oxacillin (1 ?g) and cefoxitin (30 ?g) by modified Kirby Bauer disc diffusion method. Inducible resistance to clindamycin in S. aureus was tested by ‘D test’ as per CLSI guidelines. Results :- Out of 238 Staphylococcus aureus isolates, 128 (53.7%) were methicillin sensitive (MSSA) and 114(47.8%) methicillin resistant (MRSA). Over all 26(18%) isolates showed constitutive resistance (MLSBc), 50(35%) inducible clindamycin resistance, 68(47%) MSB phenotype. Constitutive and inducible resistance to clindamycin were significantly higher in MRSA than MSSA (P

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