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Paper Details

SIMPLE SPECTROPHOTOMETRIC ESTIMATION OF LABETALOL IN BULK AND MARKETED FORMULATION

SIMPLE SPECTROPHOTOMETRIC ESTIMATION OF LABETALOL IN BULK AND MARKETED FORMULATION

Padmavathi P Prabhu*, Paramita Das, AnkurKaneria, Jithendar Reddy M

Journal Title:European Journal of Biomedical and Pharmaceutical Sciences
Abstract


Two simple, sensitive and specific methods have been developed for the quantitative estimation of Labetalol in bulk and pharmaceutical dosage form. Method A is based on oxidation of labetalol with ferric chloride followed by complex formation of resulting ferrous ion(Fe2+)with 1,10- phenanthrolin to form orange red colored chromogen which showed at 509nm.MethodB forms blue color chromogen with Gibbs reagent in alkaline condition by electrophilic aromatic substitution giving maximum absorbance 655nm.The methods were validated as per ICH guidelines.

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