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Paper Details

SYNTHESIS AND STUDY OF POTENTIAL COGNITION ENHANCERS DERIVED FROM M –NITROPHENOL

SYNTHESIS AND STUDY OF POTENTIAL COGNITION ENHANCERS DERIVED FROM M –NITROPHENOL

Yogita Dobhal*, Richa Gupta and Anurag Krishna

Journal Title:European Journal of Biomedical and Pharmaceutical Sciences
Abstract


Objective: Synthesis and evaluation of some potential memory enhancer derivatives from m-nitrophenol. Materials and methods: m-nitrophenol on refluxing with 1-bromo-3-chloropropane in ethyl methyl ketone in presence of anhydrous potassium carbonate synthesize the intermediate (38) which on treatment with acylic/ heterocyclic ring systems ( N, N-diethyl amine and various cycloamino moieties such as pyrrolidine, morpholine, N-methyl piperazine and imidazole) synthesize target compounds ( D1-D5) which were screened for nootropic activity. Transfer latency on elevated plus maze was used an index of learning and memory process. Results: Pharmacological results are expressed as % retention (Mean ± SEM) using ANOVA followed by Dunnet’s test using Sigma stat. Conclusion: All compounds possess considerable memory enhancing activities when compared with control and standard drug, piracetam (1 mg/kg) of body weight.

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