FORMULATION AND EVALUATION OF PULSATILE SALUBUTAMOL SULPHATE TABLET IN CAPSULE PULSATILE RELEASE DEVICE FOR ASTHMA
M.Gnana Prasanna Lakshmi*, M.Surya Prabha, S.S.Manikiran, N.Rama Rao
Journal Title:European Journal of Biomedical and Pharmaceutical Sciences
That the drug should not be released at all during the initial phase of dosage form administration. Such a release pattern is known as pulsatile release. In the present research work, we have attempted to
develop a novel dosage form by using a chronopharmaceutical
approach. This novel system or a technique consists of one i.e. the immediate release powder and the extended release tablet. This novel system is a so-called “tablet in capsule”. The object of this study is to formulate and evaluate pulsatile tablet in capsule device of salbutamol sulphate drug by using HPMC K100M and HPMC K15 polymers. Keywords: pulsatile drug delivery system, salbutamol sulphate, tablet in capsule device.