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Paper Details

EFFECTS OF SOME ANTIOXIDANT VITAMINS AND CHELATING AGENT ON BIOCHEMICAL ALTERATIONS IN HYPERCHOLESTEROLEMIC RATS.

Arafa, M.M, Aly S. A. and Shaheen, N.E*

Journal Title:World Journal of Pharmaceutical Research
Abstract


A total number of sixty adult male Wistar rats were used in this study to investigate the protective effects of vitamin C (vit C), vit E and EDTA alone and their combinations on hypercholesterole mia through markers of lipid profile, thyroid function, some liver and oxidativeenzymes. Rats were randomly divided into six groups (n = 10). Group I: normal control, Group II: hypercholesterolemic rats, Groups III: received ethylenediaminetetraacetic acid (EDTA) (1gEDTA/kg 1g/Kg), group IV: received 1gml/Kg body weight of vit C, group V: received vit E1g/Kg feed and Group IV received EDTA, vit C and vit E. The results of this study showed that ration supplemented with EDTA, VC and vit E either individual or in a Combination group induced significant decrease (P

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