CO-PROCESSING EFFECT OF MICROCRYSTALLINE CELLULOSE/PRE-GELATINIZED MAIZE STARCH ON PROPERTIES OF DIRECTLY COMPRESSED FOLIC ACID TABLETS.
*Mohammed, B. B
Journal Title:World Journal of Pharmaceutical Research
A binary mix powder containing various proportions of
microcrystalline cellulose(MCC) and pregelatinized maize starch
(PGS) was obtained, pelletized into 500 mg compacts, comminuted
into granules which were compressed into 75 mg tablets containing 5 mg of folic acid powder using the direct compression method. The effect of the proportion of the binary components and compaction
pressure on the proportion of comminuted pellets fines, mean granule size and tablet properties, were evaluated.The proportion of MCC in the binary mix was directly related to the proportion of fines produced
and indirectly related to the mean granule size, showing that MCC had
a lower binding effect than MCC. Increase in compaction pressure
reduced tablet thickness, increased tablet hardness and reduced friability. This is due to higher densification effect on the tablets. PGS
produced tablets with longer disintegration time (13.5 mins) compared to pure MCC content (0.8 mins). This showed that MCC is a better disintegrant than PGS.