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Paper Details

REVIEW ON DIFFERENT BARIATRIC PROCEDURE WITH POST OPERATIVE PROBLEM AND NUTRITIONAL COMPLICATION IN RATS

Ramji Gupta*, Surya Prakash Singh, Saurabh KumarVind, Sokindra Kumar, Arshad Parwez, Preeti Singh

Journal Title:World Journal of Pharmaceutical Research
Abstract


Obesity is a progressive metabolic disease that decrease life span of human and associated with a wide range of problems ranging from heart disease and diabetes to infertility and cancer. Loss of weight can significantly help to cure and reduce the chances of future health problems. Approximately nearly 10% body weight loss occur through anti-obesity drugs, but it not confer clinically benefit in patients with a body mass index exceeding 40 kg/m2, for whom bariatric surgery is indicated. The number of bariatric operations increase worldwide in recent few years with the Roux-en-Y gastric bypass (gastric bypass) is the most commonly performed operation. It is important to understand the physiological mechanisms by which gastric bypass induces and maintains body weight loss. The bariatric operations in rat model have not only mimic time profile as well as magnitude of human weight loss but also allow researchers to control post operative critical physiological factors and associated complications. The aim of this article is to summarize and discuss the technical, experimental aspect as well as etiology associated with the risk and benefit of bariatric surgery.

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