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Paper Details

SYNTHESIS AND CONFORMATIONAL STUDIES OF N-(3Z)-5-FLUORO-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YLIDENE]-3-CARBOHYDRAZIDE WITH SPECIFIC PHARMACOPHORIC FEATURES.

Shazia Haider, Zafar Saied Saify, Afshan Naz, Kaniz Fizza , Tabinda Z. M, A.Arain, Toqeer ahmed Rao, *Seema Ashraf, Dr. Abdul Ghaffar

Journal Title:World Journal of Pharmaceutical Research
Abstract


Isonicotinic acid hydrazide (isoniazid,INH) and isatin are potential bioactive agents[1-5].Tuberculosis (TB) remains a major cause of mortality throughout the world. Resistance of Mycobacterium tuberculosis to antituberculosis drugs becomes very serious problem [6]Isonicotinic acid hydrazide (isoniazid, INH) belongs to the group of the first line antituberculosis drugs being in clinical practice over 50 years. Chemical modifications of isonicotinic acid hydrazide were performed on all parts of the molecule, but the activity of these derivatives against M.

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