STUDY OF CROSS-LINKED SODIUM RBOXYMETHYLCELLULOSE (NACMC) AS AN ALTERNATIVE SUPERDISINTEGRANT IN FAST DISSOLVING FORMULATION.
A. S. Kulkarni, S. H. Majumdar, N. H. Aloorkar, K. M. Karande, Dada D. Kodalkar*
Journal Title:World Journal of Pharmaceutical Research
The present study was aimed towards the formulation and evaluation of Fast dissolution tablets of The ophylline using Cross-linked Sodium
carboxymethylcellulose. Fast disintegrating tablets of Theophylline was prepared using three different super disintegrants Namely
crospovidone, cross-linked sodium carboxymethylcellulose,and Non cross-linked sodium carboxy methylcellulose, and with three concentrations (2%, 3% and 5%) were prepared by direct compression
method. The final blend of the drug and excipients were evaluated for powder flow properties, bulk density, tapped density and
compressibility index. All the formulations were evaluated for weight variation, thickness, disintegration time,hardness, friability, wetting time and water
absorption ratio. Formulation F3 showed thelow est disintegration time. In vitro dissolution studies revealed that formulation F3 showed96.36 % percent drug release at the end of 30
minutes. These results revealed that the formulation F9 containing. Cross-linked sodium
carboxymethylcellulose (5%)as super disintegrant was better one which satisfied all the criteria as a Fast Disintegrating tablets.