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Paper Details

DESIGN AND INVITRO EVALUATION OF NON ERODIBLE POLYMERIC MATRIX TABLETS OF ISONIAZID USING SINTERING TECHNIQUE

*Raju. Manda, Virajaji Kaya, Bonagiri Sreedevi, Rachamalla Sai Santhosh and Dr.R.Suthakaran

Journal Title:World Journal of Pharmaceutical Research
Abstract


Tubercul osis rampant infectious disease is considered to be the foremost cause of death caused by Mycobacterium tuberculi. I soniazid (300 mg ) is a one of t h e m o s t important first line drug recommended by World Health Or ganization (WHO) for the treatment of tuberculosis. I soniazid and different proportions of additives were mixed. Tablets containing 300 mg equivalent to Isoniazid were compressed (surface lubricated with magnesium stearate) on sixteen punch tableting compression machine. From the invitro dissolution data, it can be conclude d that Eudragit RL 100 had retarding capacity of drug from being released. This retardant capacit y was more in E4 sintered at 4.5 hr as compa red to all other formulations and release kinet ics model follows Higuchi diffusion model. No statistically significant differences were observed the release profile of optimized formulation E4 sintered at 4.5 hr and also release kineti cs were unaltered lastl y no significant phy sical characterist ics were changed when stabilit y stud y was done for three months 40 0C 20C at 75% RH & 5%RH. From the above it was concluded that formulation E4 sintered at 4.5 hr was stable in short term stabilit y study .

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