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Paper Details

IN VITRO CYTOTOXICITY EFFECT OF MANGROVES AGAINST NON-SMALL CELL LUNG CARCINOMA A549 AND NCI-H522

C. Ravinder Singh and K.Kathiresan

Journal Title:World Journal of Pharmaceutical Research
Abstract


This is the study mainly focused on to find the anti-prolifertative effect of field grown and tissue cultured callus materials. The mangrove species Acanthus ilicifolius, Callophyllum inophyllum and Excoecaria agallocha and two different non-small cell lung cancer cell lines A549 and NCI-H522 were used for this present investigation. Cytotoxicity studies were conducted with root extracts of Acanthus ilicifolius, Callophyllum inophyllum and Excoecaria agallocha and its respective calli. The results were recorded from different concentration at different time interval. It is likely to point out that all the roots and root calli extracts these mangroves showed the toxicity activity. The root callus of all the studied mangrove extracts exhibited the better activity against both A549 and NCI-H522 than the field grown root extracts. Among the different concentrations tried, 6.5 mg/ml was f ound to be the optimum concentration for both the A549 and NCI-H522 lung carcinoma. This present study revealed that the mangrove species Acanthus ilicifolius, Callophyllum inophyllum and Excoecaria agallocha have the anti-proliferative effect and it may lead to new drug development for this leading cause of global disease.

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