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Paper Details

SOLUBLE GUANYLYL CYCLASE ACTIVATOR BAY 41-2272 IMPROVES VASCULAR ACTIVITY OF THORACIC AORTA ISOLATED FROM DOCA HYPERTENSIVE MALE WISTAR RATS

ShahidPrawez*, Azad A Ahanger2 , Kathirvel Kandasamy, Thakur U Singh, Santosh K Mishra and Souvendra N Sarkar

Journal Title:World Journal of Pharmaceutical Research
Abstract


Hypertensionis the most common cardiovascular disease and of great concern to public health. Bay41-2272 a soluble guanylylcyclase activator induces vasodilation and reduces mortality. DOCA hypertensive group envisaged administration of Deoxycorticosterone acetate salt in soyabean oil in unilaterally nephrectomised male wistarrats @25mg/kg b. wt. subcutaneously twice in a week for 4-weeks with a provision of drinking water containing sodium chloride (1%) ad lib. Sham control unilateral-nephrectomised male wistar rats were treated with soyabean oil providing normal tap water. After completion of four weeks, rats were anaesthetized with pentobarbital sodium to evaluate Mean Arterial Pressure (MAP) and found significant increase (P

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