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Paper Details

PHYTOCHEMICAL SCREENING AND STUDIES ON THE EFFECTS OF ORAL ADMINISTRATION OF PALM WINE EXTRACT OF DATURA STRAMONIUM ON THE ACTIVITY OF TISSUE ENZYMES AND HISTOPATHOLOGY OF ALBINO RATS.

Sanni, M., Ejembi, D. O., Abbah, O. C., Olajide, J.E, Ayeni, G., Usman, S.S., and Salifu, M

Journal Title:World Journal of Pharmaceutical Research
Abstract


Phytochemical screening and the effects of oral administration of palm wine extract of Datura stramonium on the activity of tissue enzymes and histopathology of rats was investigated. Forty (40) experimental rats of average weight of 100-150g were divided into four groups; A, B, C, and D comprises ten (10) rats each. Subgroups A, B, and C were administered with varying concentrations of palm wine extract of Datura stramonium, and group D served as the control group. The animals were kept in separate metabolic cages and fed with rat chow with water provided ad libitum. Rats in each group (A, B, C) where given 0.5ml/ kg body weight of the extract per day and sacrificed after day 7, 14, and 21. Rats in the control group (D) were given 0.5ml/ kg body weight of fresh palm wine daily. The enzyme activities acid phosphatase (ACP), aspartate amino transferase (AST) and alanine amino transferase (ALT) were measured. The serum total protein was measured using Biuret method. Histological analysis was carried out on the tissues (kidney, liver and intestine). A significant increase (p

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