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Paper Details

GREEN SYNTHESIS OF NANOSILVER AND ITS EFFECT ON PHASE SOLUBILITY OF FEW BCS CLASS II DRUGS

Dr. Ajit Shankarrao Kulkarni*, Mr. Kailas Madhukar Karande, Dr. Nagesh Hanumantrao Aloorkar, Mr. Jayprakash Sitaram Suryavanshi

Journal Title:World Journal of Pharmaceutical Research
Abstract


Nanometals are developing tools for drug delivery systems owing to their unique properties viz. surface plasmon resonance, high surface to volume ratio, ability to interact not only with biomolecules but also drug molecules, precise therapeutic targeting etc. These core properties pertaining to drug delivery make them potential tool in pharmaceutical research.In present investigation, silver nanoparticles were synthesized using bioexcreta, cow urine and gelatin as stabilizing agent. Synthesized nanosilvers were characterized by absorption spectroscopy, infrared spectroscopy, transmission electron spectroscopy and XRD. Absorption spectroscopy revealed successful synthesis of nanosilver. Fourier transform infrared spectroscopy showed contribution of functional groups stabilizing nanosilver. TEM depicted spherical uniform size and shape of nanosilver. XRD study revealed face centered cubic crystals. These nonfunctionalized nanosilvers were subsequently evaluated for acute toxicity study and found safe. Studies were also extended to confirm effect of synthesized NS on phase solubility of simvastatin and atorvastatin, and revealed appreciable increase in solubility of these drugs. Present investigations suggest that a green method can be used to synthesize NS which is ecological, economical, and time efficient. Further, NS could enhance solubility of simvastatin and atorvastatin.

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