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Paper Details

A MICROWAVE ASSISTED ONE POT SYNTHESIS OF TICLOPIDINE HYDROCHLORIDE THROUGH 4,5,6,7 -TETRAHYDRO (3,2-C) THIENO PYRIDINE HYDROCHLORIDE

M. M. V. Ramana* and Rajesh K. Rao

Journal Title:World Journal of Pharmaceutical Research
Abstract


The microwave assisted Pictet Spengler reaction of thiophene ethyl amine and formaldehyde afforded 4,5,6,7-tetrahydro (3,2-c) thieno pyridine hydrochloride (I), which was then subjected to alkylation with 2-chloro benzyl chloride under microwave conditions to afford Ticlopidine Hydrochloride, thus making it one-pot, efficient and economical approach.

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