• We are available for your help 24/7
  • Email: info@isindexing.com, submission@isindexing.com


Paper Details

A NOVEL AND FACILE ONE STEP PROCEDURE FOR THE SYNTHESIS OF 2-SUBSTITUTED BENZIMIDAZOLES FROM ONITRO ANILIDES IN AQUEOUS MEDIA

Dasari Raju, Gaddam Prabhakar, Dr.B.Madhavarao, Dr. .M.Choudary*

Journal Title:World Journal of Pharmaceutical Research
Abstract


A new method for the synthesis of 2-substituted N-H benzimidazoles was achieved in one step by reaction with Na2S2O4 via a reductive cyclo dehydration of o-nitro anilides in water. It was observed that Methanol or Ethanol could also be used as co-solvent. This method provides facile access to a series of 2-substituted N-H benzimidazoles (la-ln) containing various functional groups in good to excellent yields.

Download