FORMULATION AND EVALUATION OF AZITHROMYCIN SOLID DISPERSION USING POLOXAMER
T. Raja Sekharan*, Appikatla Deepthi, R. Kannan, Ganapathi Thappatla and
Journal Title:World Journal of Pharmaceutical Research
Solid dispersion technique is used to improve the dissolution/
bioavailability of poorly water soluble drug. When the drug is
incorporated with water soluble carriers the dissolution /bioavailability
can be increased. Azithromycin is a poorly water soluble drug. In this
study azithromycin solubility is increased with the help of poloxamer
188 and 407. The solid dispersion was prepared by solvent evaporation
method. The drug and the carrier compatibility study were determined
with the help of IR spectroscopy. The prepared formulations were
evaluated for percentage yield, drug content and dissolution studies.
With the help of dissolution datas the release kinetics was determined.
The formulations showed satisfied drug release.