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Paper Details


M.Suriyavathana*, A. Praveena and G.M.Keerthana

Journal Title:World Journal of Pharmaceutical Research

Several studies are going on worldwide to find natural antioxidants from plant origin which possess strong antioxidant activity with less side effects. A report about the phytochemistry of the the stem of T. asiatica showed that they contained some alkaloids. Crude alkaloids were separated from the stem and as far as our literature survey could ascertain, no information was available on the in vitro antioxidant activities of the alkaloids of the stem. So, this study was conducted to investigate the free radical scavenging activity of the crude alkaloids. For the determination of in vitro antioxidative capacity, established assay methods such as 1, 1-diphenyl 2-picryl hydroxyl (DPPH) radical assay, reducing power, ferric ion chelating assay, superoxide anion, nitric oxide scavenging activity and lipid peroxidation inhibition assays were used with reference to synthetic antioxidant ascorbic acid. The free radical scavenging properties of the alkaloids increases with increase in concentration of 150-750 g/ml and they were comparable to the standard ascorbic acid. Our findings provide evidence that the crude alkaloid extract of Toddalia asiatica.L is a potential source of natural antioxidants, and this justified the plants uses in folkloric medicines.