AN OVERVIEW: THE NOVEL CARRIER FOR VESICULAR DRUG DELIVERY SYSTEM
Dinesh Chandra*, Kamlesh Km Yadav, Vijay Kumar Singh, Anand Patel, Shashi Chaurasia
Journal Title:World Journal of Pharmaceutical Research
The focus of this review is to development of a novel drug delivery
system. Novel drug delivery system aims to deliver the drug at a rate
directed by the needs of the body during the period of treatment, and
channel the active entity to the site of action. A number of novel drug
delivery system has emerged encompassing various routes of
administration, to achieve controlled and targeted drug delivery.
Encapsulation of the drug in vesicular structure is one such system,
which can be predicted to prolong the existence of the drug in systemic
circulation, and reduce the toxicity, if selective uptake can be achieved.
Consequently a number of vesicular drug delivery system such as
liposomes, niosomes, sphinosomes, transferosomes and pharmacosomes are used to improve
the therapeutic index of both existing and new drug molecules by encapsulating an active
medicament inside vesicular structure in one such system. The era of vesiclular delivery has
much to explore by achieving success in various upcoming systems such as aquasomes,
cryptosmes, discomes, emulsomes, enzymosome, genosomes, photosomes, virosomes,
vesosomes, proteosomes etc. The approaches like pro vesicular drug delivery, coating of
vesicles, layerosomes, ufosomes system etc have also been developed which have better
stabilities in comparison to simple vesicular drug delivery systems.