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Paper Details

SPECTRAL CHARACTERIZATION AND DOCKING STUDY OF NEWLY SYNTHESIZED BENZOTRIAZOLE DERIVATIVES

*Maruthamuthu, Shameela Rajam, Christina Ruby Stella

Journal Title:World Journal of Pharmaceutical Research
Abstract


Some novel benzotriazole derivativeswere synthesized and their interaction with proteins was studied through docking. The reaction of o-phenylenediamine with sodium nitrite, yield benzotriazole. The title compounds were synthesized by treating benzotriazole with CH3COCl, C6H5COCl, C6H5Cl,C6H5NH2Cl and C6H5NH2Cl. Their structures were confirmed by IR 1 H-NMR and 13 C-NMR. Docking study was done and the compounds Aand C were found to fit well with the target protein COX-1.

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