PROTECTIVE EFFECTS OF AEGLE MARMELOS IN LEAD INDUCED GENOTOXICITY IN BONE MARROW CELLS OF MICE.
K.Rudrama Devi, Ch.Prabhakar Reddy and J.Karuna Kumari.
Journal Title:World Journal of Pharmaceutical Research
In the present studies, the protective effects of Aegles marmelos fruit
extract has been evaluated against Lead nitrate induced micronuclei in
bone marrow cells of mice. Single I.P treatement of Aegles marmelos
fruit extract of various test doses 200, 400 & 600 mg/kg had shown
non toxic nature in bone marrow cells of mice. In Lead nitrate treated
groups, there is a significant increase in the frequency of micronuclei
in polychromatic erythrocytes of mice when compared with control
values. However, along with Lead nitrate when animals were primed
with Aegles marmelos fruit extract there is an inhibition in the
frequency of micronuclei was observed at all dose levels. Thus that
clearly indicate protective effects of Aegles marmelos fruit extract
against Lead nitrate induced genotoxicity in bone marrow cells of mice. Therefore the data
showed Aegles marmelos fruit extract is a safer dietary component in heavy metal induced
DNA damage in cancer chemotherapeutic strategy.