EFFECT OF RAPHANUS SATIVUS ROOT EXTRACT ON GLUCOSE TOLERANCE IN GLUCOSE-LOADED HYPERGLYCEMIC MICE
Asaduzzaman, Prashanta Kumer Paul, Shahadat Hossan, Shahnaz Rahman, Mohammed Rahmatullah*
Journal Title:World Journal of Pharmaceutical Research
In oral glucose tolerance test (OGTT), m ethanol extract of Raphanus
sativus roots, when administered orally to glucose-loaded Swiss albino
mice at doses of 50, 100, 200 and 400 mg/kg body weight led to dosedependent reductions in blood glucose levels. At these doses, the
percent reductions in blood glucose levels were, respectively, 21.9,
34.0, 39.7, and 53.9% compared to control animals. A standard
antihyperglycemic drug, glibenclamide, when administered at a dose of
10 mg/kg body weight reduced blood glucose levels by 49.2%.
Preliminary phytochemical screening showed presence of alkaloids,
flavonoids, and saponins in the extract, which components can be
responsible for the observed blood glucose lowering effect.