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Paper Details

MICROWAVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL METAL-COMPLEXES WITH SCHIFF BASE DIETHYL 5-AMINO 4-METHYL THIOPHENE 3,5-DICARBOXYLATE-2,6-DIACETYLPYRIDINE

Dr.Mohammed.Fakruddin Ali Ahamed.*, Dr.Venkatesan Jayakumar

Journal Title:World Journal of Pharmaceutical Research
Abstract


A series of some Schiff base complexes of Cu(II),Ni(II),Cr(II),Co(II), with a penta-dentateSchiffs base Diethyl 5-amino 4-methyl thiophene 3,5-dicarboxylate -2,6- Diacetylpyridine(DAMT-DAP) has been synthesized under microwave conditions. The process is economical, easy, environment friendly and provides better yields of metal complexes in a shorter period of time. All the synthesized metal complexes and ligand were characterized on the basis of elemental analysis, 1 H -NMR, IR and mass spectral data and study of antibacterial activity. The Schiff base and metal complexes displayed good activity against the Gram-positive bacteria Staphylococcus aureus, the Gram-negative bacteria Escherichia coli and the fungi Aspergillusniger and Candida albicans. The antimicrobial results also indicated that the metal complexes displayed better antimicrobial activity as compared to the Schiff bases.

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