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Paper Details

PREPARATION AND BIO-POTENTIAL CHARACTERIZATION OF Zn(II), Cd(II) AND Hg(II) COMPLEXES WITH PHENYLACETYLUREA AND BENZOATE ION LIGANDS

A.Arunachalam*, T.Ramachandramoorthy, S.Padmavathy and R.Narendran

Journal Title:World Journal of Pharmaceutical Research
Abstract


Phenylacetylurea (PAU) is a biologically active, neutral bidendate ligand. The present study deals wit h the microwave assisted preparation, physico-chemical, spectral and biological characterization of Zn(II), Cd(II) and Hg(II) complexes containing PAU and benzoate ion (ben) ligands. The complexes were prepared by microwave irradiation technique. The molecular formulae of the complexes were arrived at from the estimation of metals and electrical conductivity values. The electronic spectral data confirm the entry of ligands into the coordination sphere of the metals. The antibacterial and anti fungal screening of the three complexes against the bacteria, viz., Raoultella planticola, Vibro cholera, Lactobacillus brevis, Pseudomonas aeruginosa, Micrococus luteus and fungi, viz., Candida albicans, Aspergillus oryzae, Aspergillus niger, Aspergillus flavus and Aspergillus sojae were carried out. The results indicate that Hg(II) complex exhibits higher antibacterial activity against Raoultella planticola, Vibro cholera, Lactobacillus brevis, Pseudomonas aeruginosa, Micrococus luteus than Zn(II) complex, Cd(II) complex and pure ligands. All the complexes show high antifungal activity against Candida albicans, Aspergillus oryzae, Aspergillus niger, Aspergillus flavus and Aspergillus sojae. The diphenylpicrylhydrazyl free radical scavenging activity of the above three complexes are lower than the standard compound, vitamin-C.

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