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Paper Details

BIOLOGICAL EVALUATION OF AZA-HETEROCYCLIC DERIVATIVES AND THEIR INTERMEDIATES

Erum Dilshad, Bushra Mirza*, Muhammad Shabbir, Zia-ul- Haq, Zareen Akhter

Journal Title:World Journal of Pharmaceutical Research
Abstract


The objective of present study was to carry out biological evaluation of aza-heterocyclic derivatives including methoxy, phenoxy, alkyl and aryl derivatives of pyrazoles and their intermediates i.e. diketones. All of the compounds were evaluated to find their potential as antimicrobial, antioxidant and antitumor agents. Antimicrobial screening was done by finding the bactericidal and fungicidal activity of the test compounds using agar well diffusion and agar tube dilution methods. Antioxidant potential was examined by DPPH free radical scavenging and DNA damage assays. Whereas antitumor findings were based on the potato disc tumor assy. Among all the tested compounds, 2-(5-(4-hydroxyphenyl)-1-phenyl-1H- pyrazol-3-yl)phenol (IX), a pyrazole having three phenyl groups has shown the highest antimicrobial, antitumor, and DNA protective activity while the compound 1-(2-hydroxyphenyl)-3-(2 methoxyphenyl)propane-1,3-dione (I) has shown the best antioxidant potential. Data obtained from these experiments indicated the possible biological activities of these compounds and enabled us to compare these compounds as antimicrobial, antioxidant and antitumor agents. On the basis of these findings, efforts for the pharmacological applications of these heterocyclic compounds can be initiated.

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