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Paper Details

IN VITRO EFFECTIVITY PARA METHOXY CINNAMATE ACID (PMCA) IN SOLID LIPID NANOSTRUCTURE (SLN) SYSTEM USING CETYL ALCOHOL AS LIPID FORMULATED IN HPC-H GEL BASE

Noorma Rosita*, Widji Soeratri, Tristiana Erawati, Ayunanda, Wakhida Fitriyani

Journal Title:World Journal of Pharmaceutical Research
Abstract


Introduction: In vitro effectivity of solid lipid nanostructure (SLN) as carrier system has been studied on para methoxy cinnamate acid (PMCA) as a means of releasing PMCA and penetrating to prolong antiinflamasi preparation. Methods: SLN was made using cetyl alcohol as lipid and Tween 80 as stabilizer, produced by high shear homogenisatian (HPH) method. SLN was then formulated in HPC-H 3% gel base. Release study were conducted in phosphat buffer medium pH 7,40,05 at 32C and stirred at 100 rpm using apparatus type 5-paddle overdisk. Penetration study were investigated in same medium at 37C by using Wistar male rat skin 2-3 month age and weight 115-180 gram, as a membrane. Results: Both PMCA released and penetrated PMCA concentration was measured spectrophotometrically at 286 nm as ? max. Spherical SLNAPMS with particle size of 26-265 nm and 64.86% drug entrapment were produced. PMCASLN had pH 3,790,05 in HPC-H gel. In vitro release and penetration study were investigated using PMCA only (F-I), PMCA in macroemulsion (F-II) and PMCA-SLN (F-III) which was formulated in gel HPC-H. PMCA which was dispersed in gel had largest release and higher penetration, followed by PMCA in macroemulsion and lastly PMCA-SLN. Release flux for formula PMCA only, PMCA in Macroemulsion and PMCA-SLN were 62,6969 1,33; 48,7949 1,07 and 27,4652 0,84 g/cm2/second- , whereas penteration flux were 0,3065 0,1470; 0,1795 0,0634 and 0,2925 0,0996 g/cm2/second1 for formula I, II and III respectively. Conclusion: SLN system has been able to retard released and penetrated PMCA.

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