BIOLOGICAL EVALUATION OF GARLIC LEAVES EXTRACTS FOR CARBOHYDRATE METABOLISM, IN VITRO
Gangadhar A. Meshram*, Tanushri S. Kulkarni, Ganesh S. Metangale, Shraddha S.
Journal Title:World Journal of Pharmaceutical Research
Allium Sativum. Linn (Garlic) is one of the widely used herbs in food
and medicine. The cloves of garlic are investigated for anti-diabetic
potential; however, no efforts have been made to explore the potential
of leaves to modify carbohydrate metabolizing enzymes viz. ?-amylase and glucoamylase. The inhibitors of these enzymes are used to
achieve greater control over hyperglycemia in Type II Diabetes
Mellitus. The present work was designed to investigate the inhibitory
potential of the different extracts of Allium Sativum, on enzymes ?-amylase and glucoamylase. Different concentrations of the extracts
were used to study inhibition of enzymatic activity of those enzymes.
The current study for the first time, revealed ?-amylase and
glucoamylase inhibitory potential of A. Sativum leaves and the study could be helpful to
isolate and characterize hypoglycemic compounds.