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Paper Details

PROTECTIVE EFFECTS OF SOLANUM LYCOPERSICUM FRUIT EXTRACT ON LEAD INDUCED MICRONUCLEI IN BONE MARROW CELLS OF MICE

*K Rudrama Devi and K Dilip Reddy

Journal Title:World Journal of Pharmaceutical Research
Abstract


In the present investigation the antimutagenic effect t of solanum lucopercicum fruit extract has been evaluated against lead nitrate induced genotoxicity. Single IP administration of solanum lycopercicum fruit extract at various doses i.e. 250, 500 and 1000 mg /kg. When treated individually did not induce micronuclei in polychromatic erythrocytes of mice. A single I P of 40mg/kg of lead nitrate induced significant increase in the percentage of micronuclei in bone marrow cells of mice. However after co administration of three doses of Solanum lycopercicum fruit extract there was a dose dependent decrease in the % of micronuclei was observed. Thus the results clearly indicate the preventive effects of solanum lycopercicum fruit extract against lead induced genotoxicity in bone marrow cells of mice. Therefore the data indicate that SL fruit extract is a safer dietary component in cancer chemo preventive strategy.

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